Gabriel Leal, Wided Guedria, Hervé Panetto, Erik Proper: In the networked enterprise, the interoperability is seen as a requirement for ensuring the collaboration among partners. Therefore, an assessment for identifying the enterprise’s strengths and weakness regarding interoperability is paramount. It involves determining the gaps between where enterprises envision themselves in the future and the enterprises’ current states. Indeed, a variety of approaches were proposed in the literature. However, based on surveys, existing methods are assessing specific aspects of interoperability and focusing only on one kind of measurement. The objective of this work is, therefore, to propose a holistic assessment approach to support the interoperability development. To do so, the criteria regarding the interoperability aspects and measurements were identified and are being formalised. The enterprise systems associated with the criteria are being modelled based on Enterprise Architecture techniques. This modelling supports the identification of existing interdependencies between criteria. Finally, case studies will be used to validate the proposed approach.